International Association Against Painful Experiments on Animals

101 Misleading results from Vivisection Animal Experiments

100: Drug Danger Undetected

The anti-inflammatory drug Ibufenac was marketed in Britain during 1966 but withdrawn two years later following 12 deaths, mainly through liver damage. Although submitted to "extensive" tests in mice, rats and dogs, no evidence of liver damage was detected except for a slight effect in rats exposed to lethal doses of the drug.(1)

Dr Cuthbert of the Medicine's Division at Britain's Department of Health and Social Security, explained that "Evidence of liver damage is sometimes detected in animal studies of non-steroidal antiinflammatory drugs but usually no such evidence is forthcoming even in circumstances where a drug is eventually shown to be hepatotoxic (damaging to the liver) in man."(1)


I) M.F.Cuthbert in Current Approaches in Toxicology, Ed. B.Ballantyne (Wright & Sons, 1977).

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