The antidepressant drug mianserin can cause potentially fatal blood disorders and the British National Formulary recommends that patients should have full blood counts every 4 weeks during the first 3 months of treatment.(1) By early 1988 the World Health Organisation Collaborative Centre for International Drug Monitoring had collected 321 reports referring to white blood cell disorders. The effects had not been predicted by animal tests,(2) but subsequent studies showed that they could be observed in test tube experiments with human tissues.(3)
I) British National Formulary, No.26 (BMA & the Royal Pharmaceutical Society of GB, 1993).
2) H.M.Clink, British Journal of Clinical Pharmacology, 1983, vol.15, 291S-293S.
3) P.Roberts et al, Drug Metabolism & Disposition, 1991, vol.l9, 841-843.
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