The diuretic drug Selacryn was introduced in 1979 but withdrawn from the US market only a year later after 363 reports of liver damage including 24 fatalities.(1) In many other countries, including the UK, development of the drug was cancelled.(2) Selacryn's harmful effects were unexpected since they had not been detected in animal experiments. (1)
1) S.Takagi et al, Toxicology Letters, 1991, vol.55, 287-293.
2) C.Spriet-Pourra & M.Auriche, Drug Withdrawal from Sale (PJB Publications, 1988).
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