Domperidone is used for the treatment of nausea and vomitting, particularly that caused by anticancer drug therapy. In 1986 the injectable form of the drug was withdrawn worldwide (1) because of potentially hazardous heart rhythm disturbances. The dangers had not been predicted by animal experiments (2) and in dogs, the animal traditionally used to assess effects on the heart, more than 70 times the recommended human dose produced no changes in the electrocardiogram.(3)
1) C.Spriet-Pourra & M.Auriche, Drug Withdrawal from Sale,( PJB Publications,1988).
2) R.Heywood in Animal Toxicity Studies: Their Relevance for Man, Eds. C.E.Lumley & S.R.Walker (Quay Publications, 1990).
3) R.N.Brogden et al, Drugs, 1982, vol.24, 360-400.
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