Prenylamine, a treatment for angina, was withdrawn from the UK market in 1988,(1) the main problem being that the drug caused ventricular tachycardia, a condition in which the heart beats abnormally fast. The side-effect caused patients to faint. In contrast, animal experiments carried out at the University of Eoteborg in Sweden revealed that in cats, rabbits and guinea pigs, prenylamine reduced the heart rate by up to 25%.(2) In cats, for instance, a dose of prenylamine reduced heart rate from 225 beats per minute to 171.
1) C.Spriet-Pourra & M.Auriche, Drug Withdrawal from Sale (PJB Publications, 1988).
2) H.Obianwu, Acta Pharmacology et Toxicology, 1967, vol.25, 127-140.
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