In 1951, physicians at the University of California Medical School in San Francisco, warned ophthalmologists against the prolonged use of furmethide in the treatment of glaucoma.(1) They noted that permanent obstruction of the tear passages occured in over 70% of patients where the drug was used for more than 3 months.
Eleven years earlier, researchers had reported experiments on animals' eyes, pronouncing the drug "entirely safe" and worthy of clinical trial.(2) The tests were performed on rats, guinea pigs and rabbits and continued for several months.
1) R.N.Shaffer & W.L.Ridgway, American Journal of Ophthalmology, 1951, vol.34, 718-720.
2) A.Myerson & W.Thau, Archives of Ophthalmology, 1940, vol.24, 758-760.
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