Iproniazid was originally developed as a treatment for tuberculosis but found use as an antidepressant. Although considered “harmless” on the basis of animal tests,1 iproniazid produced fatal cases of liver damage in human patients and the drug was eventually abandoned.2
1) J.Boyer in Clinical Pharmacology, Basic Principles in Therapeutics, 2nd edition, Eds. K.LMelmon & H.F.Morrelli (MacMillan, 1978)
2) B.Blackwell & J.S.Simon in Side Effects of Drugs Annual 13, Eds M N.G.Dukes & L.Beeley (Elsevier, 1989).
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