Evicromil (code name FPL 52757) was submitted for clinical trial as an antiasthmatic drug following safety evaluation in mice, rats, hamsters, rabbits, ferrets, squirrel monkeys, cynomolgus monkeys, stump-tail monkeys and baboons. Despite using doses many times greater than the amount intended for human use, no harmful effects were seen, especially with respect to the liver.(1) Yet 20% of patients participating in the trial had symptoms of liver damage, precluding any further development of the drug.(2) Subsequent tests showed that liver toxicity could only be induced in dogs.(1,2)
) D.V.Parke in Animals & Alternatives in Toxicity Testing, Eds. M.Balls et al (Academic Press, 1983).
2) C.T.Eason et al, Regulatory Toxicology & Pharmacology, 1990, vol.11, 288-307.
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