Chymotrypsin is widely used in ophthalmic surgery for the treatment of cataract. Although recommended for human use,(1) chymotrypsin is harmful to the rabbit eye. In his book Toxicology of the Eye (1974), Morton Grant states that "the rabbit cornea appears to differ significantly from the human cornea in its reaction to a -chymotrypsin. It has been noted repeatedly that introduction of a -chymotrypsin into the (rabbit's) corneal stroma...leads to severe swelling reaction of cornea, much more than is seen in human beings, and in some instances leading to perforation of the cornea.”
1) British National Formulary, No.26(BMA and The Royal Pharmaceutical Society of G.B., 1993).
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