Rabbits and guinea pigs are commonly used to assess irritancy but neither provides an accurate model for human skin.(1) For instance,by the criterion of animal experiments, hypochlorite bleach should be considered comparatively safe for human use, since it only produces "slight visible irritation" in rabbits and guinea pigs.(1) However, in human volunteers bleach causes severe skin reactions.
I) G.A.Nixon et al, Toxicology & Applied Pharmacology, 1975, vol.31, 481-490.
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